@article{3116, author = "Ying Fan and Le Li and Xiaoqing Yu and La Xu and Shuxian Wang and Chunlei Gai and Jing Diao and Xiaolu Wang and Haibin Ye and Danping Ma", abstract = " The complement system has been discovered and studied in different tissues of sea cucumber, which play a crucial role in the innate defense. As a central component in the complement system, complement component 3 (C3) is an intermediary between innate and adaptive immune system. In the present study, Codonopsis pilosula (C. pilosula) with the form of microcapsule was supplemented at 1%, 2%, 4% rate of Sargassum thunbergii diet. There was no C. pilosula in the control group. Two C3 genes (AjC3 and AjC3-2) were expressed in the coelomocytes and intestine of sea cucumbers fed with C. pilosula. The expression levels were increased significantly on the 28th day after feeding 2% C. pilosula (P0.05). Moreover the patterns of AjC3 and AjC3-2 were similar, there were significant correlations between the two. The expression levels of them were high in the coelomocytes, lower in the intestine. After feeding for 28 days, ten sea cucumbers from each group were challenged with V. splendidus. Cumulative mortality of sea cucumbers fed with C. pilosula were found to be lower than the control, especially 2% group. The results indicated that AjC3 and AjC3-2 genes played a pivotal role in immune response. C. pilosula could promote the expression of C3, enhance the immune of sea cucumber.", issn = "23191473", journal = "IJAIR", keywords = "Codonopsis pilosula;Apostichopus naponicus;Immunity;Complement Component 3;AjC3", month = "January", number = "4", pages = "290-299", title = "{E}ffect of {C}odonopsis pilosula on {E}xpression of {T}wo {D}ifferent {C}omplement {C}omponent 3 in the {S}ea {C}ucumber ({A}postichopus naponicus)", volume = "8", year = "2020", }