IJAIR NAAS Score : 3.99 ,ISSN : 2319-1473
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IJAIR NAAS Score : 3.99 (2016 - 2020)
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Bioactive Compounds Bioavailability of Microencapsulated Foshou Fruit Effervescent Tablets: in Vitro Simulated Gastrointestinal
- Amer Ali Mahdi; Qais Ali Al-Maqtari; Mohamed Ismael Ahmed; Waleed Al-Ansi; Aqsa Ahmed; Jalaleldeen Khaleel Mohammed; Hongxin Wang
- This study aimed to evaluate the extractability factor and bioavailability of phenolic compounds and antioxidant activity of effervescent tablets of microencapsulated Foshou fruit extract by in vitro simulated gastrointestinal model. Total phenolic content and antioxidant capacity of the effervescent tablets were estimated in chemical extract (CE), buffer extract (BE), the extract after simulated digestion(GE), and the extract after simulated absorption(AE). The effervescent tablets of microencapsulated Foshou fruit extract by different carrier agents formulations were used in this study, the carrier agents formulations were Gum arabic/ Maltodextrin/ Modified starch/ Whey protein (GMSW); Gum arabic/ Maltodextrin/ Modified starch (GMS); Gum arabic/ Maltodextrin/ Whey protein (GMW); Gum arabic/ Modified starch/ Whey protein (GSW); Maltodextrin/ Modified starch/ Whey protein (MSW). The GE had the highest total phenolic content (15.43 mg GAE/g tablet) and antioxidant activity (IC50 7.40 mg tablet). The GMS tablets showed the highest total phenolic content and antioxidant activity among all extracts. GMS tablets showed the highest extractability factor for phenolic compounds in BE (1.81), GE (2.82), and AE (2.43), moreover in terms of extractability factor for antioxidant activity in BE (1.28), GE (2.44), and AE (1.69). The highest bioavailability index was in MSW tablets (0.90) for phenolic compounds, and in GSW tablets (0.73) for antioxidant activity. The results of this study indicate the possibility of using effervescent tablets as a method of improving the bioavailability of phenolic compounds and antioxidants in microencapsulated Foshou fruit extract.
- Select Volume / Issue:
- Year:
- 2019
- Type of Publication:
- Article
- Keywords:
- Bioavailability; Extractability Factor; Simulated Gastrointestinal; Foshou Fruit; Effervescent Tablets; Microencapsulation
- Journal:
- IJAIR
- Volume:
- 8
- Number:
- 2
- Pages:
- 122-132
- Month:
- September
- ISSN:
- 2319-1473
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