IJAIR NAAS Score : 3.99 ,ISSN : 2319-1473
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IJAIR NAAS Score : 3.99 (2016 - 2020)
"Submissions Open For Vol. 15, Issue 1, July - Aug., 2026"
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IJAIR NAAS Score : 3.99 (2016 - 2020)
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Journals Published by TimeLine Publication Pvt. Ltd.
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IJIRES , IJASM , IJRIES,IJAHVS
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IJAIR NAAS Score : 3.99 (2016 - 2020)
"Submissions Open For Vol. 15, Issue 1, July - Aug., 2026"
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IJAIR NAAS Score : 3.99 (2016 - 2020)
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Journals Published by TimeLine Publication Pvt. Ltd.
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IJIRES , IJASM , IJRIES,IJAHVS
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IJAIR NAAS Score : 3.99 (2016 - 2020)
"Submissions Open For Vol. 15, Issue 1, July - Aug., 2026"
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IJAIR NAAS Score : 3.99 (2016 - 2020)
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Wheat Germ Oil Ameliorates Sucrose Induced Hepatosteatosis and Dyslipidemia through Controlling Lipogenic and Cholestrogenic Genes Expression in Rats
- Sahar H. Orabi; Abd Eldaim Mabrouk A.; Sherif M. Shawky; Anis Zaid
- Sucrose high diets induce hepatosteatosis and dyslipidemia while wheat germ oil has been shown to relive them. Thus this work was carried to evaluate the possible mechanisms through which wheat germ oil attenuate sucrose induced hepatostiatosis, and dyslipidemia in rats. Twenty eight male Wister albino rats were divided into 4 groups. Control group was received tap water, 2nd group was received 60% sucrose in drinking water, 3rd group was supplemented with wheat germ oil (1.5ml/kg.BW/day orally) and 4thgroup was given 60% sucrose in drinking water and supplemented with wheat germ oil (1.5ml/kg.BW/day orally) simultaneously for 30 days. Sucrose administration in rats induced hepatosteatosis, dyslipidemia and hyperglycemias. Sucrose increased blood glucose level, serum levels of triacylglycerol, total cholesterol, VLDL-c and LDL-c and mRNA expression of pyruvate kinase, hydroxymethyl glutrayl CoA reductase, and fatty acid synthase as well as it induce fatty change in hepatocytes while it decreased serum level of HDL-c. In contrast, supplementation of sucrose administrated rats with wheat germ oil enhanced hemoglobin concentration and hematocrit value and normalized the altered lipid profiles through normalizing mRNA expression of hydroxymethyl glutrayl CoA reductase, and fatty acid synthase. In addition it induced hypoglycemia through increasing mRNA expression of pyruvate kinase and reducing mRNA expression of pyruvate carboxylase as well as it restored the histological structure of hepatic tissue. This study indicated that wheat germ oil protected rats against sucrose induced hepatosteatosis and dyslipidemia through controlling lipogenic and cholestrogenic gene expressions suggesting that wheat germ oil is a promising agent against sucrose induced hepatostiatosis and dyslipidemia.
- Select Volume / Issue:
- Year:
- 2016
- Type of Publication:
- Article
- Keywords:
- Hepatosteatosis; Dyslipidemia; Wheat Germ Oil; Sucrose
- Journal:
- IJAIR
- Volume:
- 4
- Number:
- 4
- Pages:
- 619-626
- Month:
- January
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