IJAIR NAAS Score : 3.99 ,ISSN : 2319-1473

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IJAIR NAAS Score : 3.99
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IJAIR NAAS Score : 3.99
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IJAIR NAAS Score : 3.99
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IJIRES , IJASM , IJRIES,IJAHVS
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IJAIR NAAS Score : 3.99
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IJAIR NAAS Score : 3.99
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IJAIR NAAS Score : 3.99
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Journals Published by TimeLine Publication Pvt. Ltd.

IJECCE , IJEIR , IJAIR,
IJAIM , IJRAS , IJISM ,
IJIRES , IJASM , IJRIES,IJAHVS
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IJAIR NAAS Score : 3.99
"Submissions Open For Volume 9,Issue 1,July - Aug., 2020"


Successfully Published

Volume 8,Issue 6,May - June, 2020


Submissions open

IJAIR NAAS Score : 3.99
"Submissions Open For Volume 9,Issue 1,July - Aug., 2020"


Mail your paper at E-mail:

IJAIR NAAS Score : 3.99
submit2ijair@yahoo.in , submit@ijair.org


Journals Published by TimeLine Publication Pvt. Ltd.

IJECCE , IJEIR , IJAIR,
IJAIM , IJRAS , IJISM ,
IJIRES , IJASM , IJRIES,IJAHVS
https://timelinepublication.com/


Submissions open

IJAIR NAAS Score : 3.99
"Submissions Open For Volume 9,Issue 1,July - Aug., 2020"


Successfully Published

Volume 8,Issue 6,May - June, 2020


Submissions open

IJAIR NAAS Score : 3.99
"Submissions Open For Volume 9,Issue 1,July - Aug., 2020"


Mail your paper at E-mail:

IJAIR NAAS Score : 3.99
submit2ijair@yahoo.in , submit@ijair.org


Journals Published by TimeLine Publication Pvt. Ltd.

IJECCE , IJEIR , IJAIR,
IJAIM , IJRAS , IJISM ,
IJIRES , IJASM , IJRIES,IJAHVS
https://timelinepublication.com/


Submissions open

IJAIR NAAS Score : 3.99
"Submissions Open For Volume 9,Issue 1,July - Aug., 2020"


Successfully Published

Volume 8,Issue 6,May - June, 2020


Submissions open

IJAIR NAAS Score : 3.99
"Submissions Open For Volume 9,Issue 1,July - Aug., 2020"


Mail your paper at E-mail:

IJAIR NAAS Score : 3.99
submit2ijair@yahoo.in , submit@ijair.org


Journals Published by TimeLine Publication Pvt. Ltd.

IJECCE , IJEIR , IJAIR,
IJAIM , IJRAS , IJISM ,
IJIRES , IJASM , IJRIES,IJAHVS
https://timelinepublication.com/


Submissions open

IJAIR NAAS Score : 3.99
"Submissions Open For Volume 9,Issue 1,July - Aug., 2020"


Successfully Published

Volume 8,Issue 6,May - June, 2020


Submissions open

IJAIR NAAS Score : 3.99
"Submissions Open For Volume 9,Issue 1,July - Aug., 2020"


Mail your paper at E-mail:

IJAIR NAAS Score : 3.99
submit2ijair@yahoo.in , submit@ijair.org


Journals Published by TimeLine Publication Pvt. Ltd.

IJECCE , IJEIR , IJAIR,
IJAIM , IJRAS , IJISM ,
IJIRES , IJASM , IJRIES,IJAHVS
https://timelinepublication.com/



Protective Effects of Green Tea Polyphenols (GTP) on Hydrogen Peroxide (H2O2)-Induced Oxidative Stress, Inflammatory Response, and Apoptosis in Bovine Mammary Epithelial Cells (BMECs) in Vitro

Yanfen Ma; Ying Feng; Lei Zhao; Chunhua Zhang; Hua Bao; Muyang Li
The increase in metabolic demand during the periparturient period is accompanied by increasing rates of oxidative stress, as an inducer of tissue injury, cause inflammatory reaction of udder in transition dairy cows. Green tea polyphenols (GTP) are key antioxidant with potential to regulate oxidative stress and inflammation. The aim of this study was to evaluate the effect of supplementation of GTP on inflammatory response and redox balance during hydrogen peroxide (H2O2) stimulation in primary bovine mammary epithelial cells (BMECs). Primary BMECs (n = 3 replicates per treatment) were pre-incubated with or without 100 μg/mL GTP for 12 h, subsequently, cells were challenged with or without H2O2 (600 μM) and incubated for 6 h. Data were analyzed using the one-way ANOVA and two-tailed Student′s t-test of SAS 9.4. Results demonstrated that H2O2 elevated intracellular reactive oxygen species (ROS) levels and phosphorylation of p65, a biomarker of inflammation, and induced cells inflammatory response and apoptosis. Pretreatment of cells with GTP improved the BMECs survival rate and antioxidant effects during challenge with H2O2 by activating the expression of nuclear factor erythroid 2-related factor 2 (NFE2L2)/heme oxgenase-1 (HMOX-1) pathway and scavenging intracellular ROS. Treatment GTP attenuated H2O2-induced expression of an inflammatory protein, and pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) by inhibiting the activation of mitogen-activated protein kinases (MAPK)/ nuclear factor-kappa B (NF-κB) pathway. H2O2-induced cells apoptosis was strongly inhibited by inhibiting caspase/p53 pathways. Overall, these results support that oxidative stress can produce cellular inflammation and apoptosis in BMECs, and supply of GTP can alleviate the oxidative stress, inflammatory responses and cells apoptosis triggered by H2O2 through activating the NFE2L2/HMOX-1 pathway, and controlling the MAPK, NF-κB, and caspase/p53 pathway.
Select Volume / Issue:
Year:
2020
Type of Publication:
Article
Keywords:
Oxidative Stress; Inflammation; Bovine Mammary Epithelial Cells; Green Tea Polyphenols
Journal:
IJAIR
Volume:
8
Number:
5
Pages:
423-437
Month:
March
ISSN:
2319-1473
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